You will find there's launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to lessen afferent suffering transmission and create analgesia. Thus, medication like clonidine that focus on alpha-2 receptors can impact the transmission of suffering. Applies to clonidine: oral pill, https://piersu479spj8.ktwiki.com/user