Chemotherapy was potentiated by E7449 and one agent had considerable antitumor action in BRCA-deficient xenografts. Moreover, E7449 inhibited Wnt/β-catenin signaling in colon most cancers mobile traces, very likely via TNKS inhibition. In keeping with this likelihood, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and significantly altered expression https://stattic47925.ampedpages.com/not-known-details-about-xp-59-56931200