This mechanism is probably in the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the clinical response to doxycycline must be monitored carefully. Phenytoin, sodium valproate, valproic acid: The result of barbiturates on the metabolism of phenytoin seems being variable. Some investigators https://collinsz567nhr9.targetblogs.com/profile