In light of those observations, sirtuins are recognised as novel regulators of immuno-metabolism in human beings. Other than SIRT1, SIRT2 has become lately associated with cytoskeleton reworking and activation of NLRP3 in intracellular pathways[117]. Apart from the activation of innate immunity, the contribution of adaptive immune cells in inducing inflammation https://www.directivepublications.org/journal-of-diabetology-research/